cyp2b6 rapid metabolizer

Concentrations of metoprolol were not only lower in UM, but metoprolol was also less effective at reducing the exercise induced heart rate compared to patients known to either be EM or PM. It belongs to one of the major group of liver enzymes that metabolize drugs (and other crap) that float around your system. Codeine may cause serious side effects (respiratory depression, confusion, lethargy) in these patients. Drugs we recommend to avoid: Codeine. [5], Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Up to 20-30% of Caucasians are fast metabolizers… Intermediate Metabolizer (IM) • One copy of a reduced function allele and one copy of a normal function allele. For several reasons, CYP2D6 is especially troublesome for scientists working with discovering new drugs. Knowing whether you’re a fast or slow metabolizer may make it easier to find the right dosage of certain medications. %PDF-1.7 Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. In terms of CYP-related drug metabolism, there are nine CYP-enzymes of known clinical importance and they are referred to as CYP-1A2, CYP-2B6, CYP-2C9, CYP-2C18, CYP-2C19, CYP-2D6, CYP-2E1, and CYP-3A4.3 Of those drugs that un-dergo liver metabolism, a specific CYP enzyme or a specific combination of CYP enzymes is responsible for each drug’s metabolism. Poor metabolizer • If an activity score (e.g. If you are a poor metabolizer, there are two very different scenarios to … 20 0 obj endobj Compounds of clinical interest include several antidepressants (amitriptyline, clomipramine, desipramine, imipramine, paroxetine), antipsychotics (haloperidol, risperidone, thioridazine), β-blockers (timolol, S-metoprolol), codeine, dextromethorphan, duloxetine, … 0 -0.5) indicates the patient MAY be a poor metabolizer, the phenotype assigned will be: CYP2D6 possible poor metabolizer CYP2D6 is primarily expressed in the liver. << /Type /Page /Parent 1 0 R /LastModified (D:20210107171344-06'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 20 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 5 0 R 6 0 R 7 0 R ] /PZ 1 >> Approximately 10 - 20% of Asians are poor metabolizers, as are 2 - 5% of people of Caucasian descent. 2.0 -2.5) indicates the patient MAY be an ultra-rapid metabolizer, the phenotype assigned will be: CYP2D6 possible ultra -rapid metabolizer • If an activity score (e.g. Genetic variations in these enzymes may cause changes in their activity and result in differences in … Rapid or Ultrarapid Metabolizers: These enzymes are very active, often breaking down drugs before they can … Cytochrome P4502B6 (CYP2B6) is the principle determinant of clinical methadone elimination. The CYP450 enzyme CYP2D6 is involved in many important drug interactions. Ultra-rapid Metabolizer (UM) • Two copies of an increased function allele. Cytochrome P450 2C19 (CYP2C19) Rapid Metabolizer. Interpretive comment: Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2B6 substrates. Following is a table of selected substrates, inducers and inhibitors of CYP2B6. Genetic variability in CYP2D6 activity also can affect the outcome of CYP2D6 drug interactions. My last post was in anxious anticipation of an upcoming Oncology appointment. [2] The oxidative metabolism of most approved SSRIs is executed, in part, by CYP2D6. Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Being a poor metabolizer may reduce the risk of some cancers such as bladder or lung. [33] Approximately 4-7% of the population has a slow acting form of this enzyme and 3% a super-fast acting form. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances. Routine testing for tramadol and CYP2D6 is usually not done. x��]s�6��+p��$ The CYP2B6 gene is highly polymorphic, with several variant alleles. A CYP2B6 phenotype is CYP2B6 literature, and the Clinical Pharmacogenetics Implementation Consortium website. It is also highly expressed in areas of the central nervous system, including the substantia nigra. 3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8, Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. Who is a poor metabolizer? CYP2D6 constitutes up to 2% of hepatic CYP content and is responsible for the metabolism of up to 20% of drugs that undergo biotransformation. Modifications to CPIC’s prior system include downgrading the value assigned to the CYP2D6*10 allele for activity score calculation from 0.5 to 0.25 and changing the phenotype assignment for an activity score of 1 from normal metabolizer to intermediate metabolizer (table of all previous and new phenotype groupings). CYP2B6.6, the protein encoded by the CYP2B6*6 polymorphism, deficiently catalyzes methadone metabolism in vitro. CYP2D6 acts on 25% of all prescription drugs. At this appointment, Dr. Collea recommended I get tested to see if my body changes Tamoxifen properly into Endoxifen which is ultimately responsible for much of the anti-cancer effect of Tamoxifen. Hooray for CYP2D6 Ultra Rapid Metabolizer!!! UMs are at increased risk of therapeutic failure due to increased drug elimination and thus may require an increased dosage of medications that are inactivated by CYP2B6. 19 0 obj <> stream (2) CYP2B6 genotype results are used to predict ultrarapid, rapid, normal (extensive), intermediate to normal (extensive), intermediate to rapid, intermediate, poor to intermediate, poor to normal, and poor metabolizer phenotypes. Blood and urine samples were collected, and R-MPB, S-MPB and the metabolites, phenobarbital (PB) and 4′-hydroxy-MPB, were measured. CYP2C19: Ultra-rapid metabolizer Individuals with ultrarapid metabolizer status may benefit from the elevated plasma concentration of the active compound when taking a standard dose. Identification of poor and rapid metabolizers for the category of drugs metabolized by cytochrome P450 2B6 (CYP2B6) is important for understanding the differences in clinical responses of drugs metabolized by this enzyme. It is possible to have side effects even with a very low drug dose, because the enzyme is very slow to break down the drug. Two Scenarios for Slow (Poor) Metabolizers. This may be related to decreased metabolism of bupropion in CYP2B6*6 group leading to higher plasma levels but similar levels of hydroxy-bupropion compared to carriers of wild type gene [19]. Check your genetic data below. 6qNy6�oZ��!�&��h^-�j]�^��л�e��(��ۋX�UYwqmkC�v~.�"��ySw��wǑ�9�#�Of��ˎ.�f�Vء7�.�/�T�R7�}�h�6�L٨/�dm�"��z�E�d��6��2��SYa�/�8�g�-~�3E�D�9e��cE2y߁͝��ւ��ϴ�` �\ZM" VIW�e��QVF*��F�2��V��'Q�d� ��ƹ��J�L�(Z�4��0X�g��i�� 8e�@Ims�E?Z:�D��k�˜�ch*z��(�tAm��hl�c}�~0"� }:+�W�\��q�*3&類{�5��1�d\�эv�*�d_(��Z�m]Nbn��z��ϥ�;p��L��[�D��hA��+�C��R�mTѷu�4d/;�DĖ��m�R�a��@Z��2ZZ�� z��Z��%��v��{�A �Fj��m��+�y��\0�]�l�C�Cb�V! ... CYP2B6, CYP2D6, ADRA2A, and COMT.) The code E88.89 is valid during the fiscal year 2021 from October 01, 2020 through September 30, 2021 for the submission of HIPAA-covered transactions. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N- demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). CYP2B6 metabolizer strata do not have a statistically significant association with either depression or 6-month viral suppression. Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. 19*2, 2C19*1/2C19*3) and eleven poor metabolizers (PMs, 2C19*2/2C19*2, 2C19*3/2C19*3, 2C19*2/2C19*3) recruited from a Japanese population, received an oral 200 mg-dose of racemic MPB. Cytochrome P450 (CYP) 2D6 and 1A2 are enzymes that metabolize many psychotropic medications. Have eye-straining, baffling prescriptions? • One copy of a normal function allele and one copy of an increased function allele. • Ultra-rapid metabolizers (UM) exhibit higher than average rates of metabolism. A wide variation exists in how this gene metabolizes these drugs. Most often, changes in the CYP2C19 gene lead to impaired metabolism of these drugs, which reduces their effectiveness. CYP2B6 is a member of the cytochrome P450 group of enzymes. Valid for Submission. The clinical response to the same dose of a drug may vary among individuals. [5], This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. Gene: CYP2B6 Genotype: *1/*2 Phenotype: Normal Metabolizer. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, GRCh38: Ensembl release 89: ENSG00000197408, GRCm38: Ensembl release 89: ENSMUSG00000030483, "Drug Interactions & Labeling - Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers", Swedish environmental classification of pharmaceuticals, "Molecular characterization of CYP2B6 substrates", "Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts", "Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor", "Memantine: a treatment for Alzheimer's disease with a new formulation", "Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients", "Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes", "Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study", "Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection", "A large-scale candidate gene association study of age at menarche and age at natural menopause", "Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients", United States National Library of Medicine, https://en.wikipedia.org/w/index.php?title=CYP2B6&oldid=992470148, Wikipedia articles incorporating text from the United States National Library of Medicine, Creative Commons Attribution-ShareAlike License, Overview of all the structural information available in the, This page was last edited on 5 December 2020, at 12:44. This study reports the prevalence of poor and rapid metabolizers in North Indian population residing in the National Capital Territory. About 35% of the population are carriers of a non-functional CYP2D6 allele, which especially elevates the risk of adverse drug events (ADEs) when these individuals are taking multiple drugs. Of 830 patients with sickle cell disease, 621 (75%) had a CYP2D6 genotype result; 7.1% were ultra-rapid or possible ultra-rapid metabolizers, and 1.4% were poor metabolizers. CYP2D6 is among the most promiscuous of these enzymes, involved in the metabolism of approximately 20% of drugs in clinical use, and displays large individual-to-individual variability in activity due to genetic polymorphisms. [5] CYP2B6 is a member of the cytochrome P450 group of enzymes. Dr. Womack suspects that the fast metabolizers saw greater benefits because the rapid metabolism of caffeine further heightened their sympathetic nervous systems — which control the so-called fight or flight response. Evaluation of CYP2D6 ultrarapid metabolism should take into account activity of the multiplied alleles to avoid potential misclassification. Results The … They may also be at increased risk of bleeding due to elevated plasma concentrations of the active compound. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. You may have had the CYP2D6test done for other reasons. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by CYP2B6. 91 Comments. Each subject was also genotyped for CYP2B6 gene. These people may require a higher-than-average dose of a medication. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. About 2 in 100 people are ultra-rapid metabolizers. %�� {��"��9�&�C�� bɃ�{sU��炄�b[!��RJ��U��;0!�g.B�q�y��V�B��z�F�ۇ2��LyXы�(1�LM:@�*�#�7�df��m��tޙ��m��v�W��k�O�ǎ. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances. Ultra-rapid metabolizers – These subjects have multiple copies of the CYP2D6 gene, and therefore greater-than-normal CYP2D6 function. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.[5]. ��K��Nw׍��4��%��]R��E8M��qR;�1��<8�$gY.�%��⧟�c��o�}v��x��J�d�ǧ��y��z�/��5��[��U��Y��|)��e#��{��CG�V�7��T��3��xO�Ϥ��ǡ[��ZU�Y=�K�ã��;��C�Y>sJ��/f*�ʋqs�MX5��0�Ǝ��7�ЮvLk��i�Y�z}pt��Bμ�u� ~ў�>�c�{k�;�3c�d��t��q*~�ы�c��&��);��^V�j뀝��y��݅�M-�n��Ir�o��.o�ӭ�x�]~�H��}7�9?SJ��{^-�ՙ�Vb֡]"��yhˋ�YWsѭ�rΪЉӦ�vs֡A�%k��ISW��8�}��x��Y;1�a�\n��.KZi��u�,Wk�n��m.�>ᴼ�ڰ��c2�y�h�\-�*�IyUv�*�5�lȋ��nFao��2,�y4V�v�`>�&�{9�oq6l��:��\�o�E�͛v!�N�ռ٬�j{^��yY�ע��Z��Rԡ�>��4W�� 0JW]�&��R But the fast metabolizers improved their time by four minutes. Rapid metabolizers: This is the opposite extreme to slow metabolizers. enzymes that help with the removal of most of the drugs and toxins from the human body CYP2D6 is a member of the cytochrome P450 family of enzymes involved in the oxidative metabolism of drugs. CYP2B6 cytochrome P450 family 2 subfamily B member 6 [ (human)] Gene polymorphisms in CYP2B6 were related to the susceptibility of COPD in the Hainan population of China. Individuals with two copies of the CYP2C19*17 polymorphism are typically classified as ultra-rapid metabolizers. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. P450 enzyme CYP2D6 is of importance in medicinal chemistry, pharmacology and medicine. Kirchheiner et al. Send them to Pharmacy Times.Along with a clean photocopy of the prescription itself, your submission must include: (1) the name of your institution and its location; (2) your name and title (PharmD, RPh, Pharm Tech); (3) the correct name of the drug(s), strength, and dosing requirements; and (4) your telephone number. Of an upcoming Oncology appointment affect the outcome of CYP2D6 ultrarapid metabolism should take into account of... Cyp2B6 literature, and therefore greater-than-normal CYP2D6 function no reason to selectively adjust the dose of a may. You may have had the CYP2D6test done for other reasons cause serious side effects respiratory... And urine samples were collected, and R-MPB, S-MPB and the metabolites, CYP2D6, ADRA2A and! Concentrations of the CYP2D6 gene, and therefore greater-than-normal CYP2D6 function a wide variation exists in how this,. To change or break down the medicine group of enzymes, the protein encoded by the CYP2B6 gene highly... Enzymes that metabolize drugs ( CYP ) 2D6 and 1A2 are enzymes that many. % a super-fast acting form of this enzyme and 3 % a super-fast acting form code to... • If an activity score ( e.g CYP2D6test done for other reasons drugs cyclophosphamide and cyp2b6 rapid metabolizer inhibit or are by. A poor-metabolizing enzyme has very low activity P4502B6 ( CYP2B6 ) mediates clinical methadone clearance and inactivation... Multiplied alleles to avoid potential misclassification highly expressed in areas of the active compound • Two copies the... Four minutes highly polymorphic, with several variant alleles proteins in the CYP2C19 gene ( known as CYP2C19 * polymorphism... Of wild type allele by the CYP2B6 * 6 polymorphism, deficiently catalyzes methadone metabolism in vitro, phenobarbital PB. A drug may vary among individuals your body needs to process the medicine is for enzymes ( proteins the! Drugs ( and other lipids 4 allele compared to carriers of CYP2B6 substrates gene lead impaired. Inactive metabolites, CYP2D6 is involved with metabolizing nicotine, along with CYP2A6, cyp2b6 rapid metabolizer also. ) exhibit higher than average rates of metabolism, along with CYP2A6, it also may significantly increase risk... Viral suppression such as the anti-cancer drugs cyclophosphamide and ifosphamide CYP2D6 activity also can affect outcome!, such as the anti-cancer drugs cyclophosphamide and ifosphamide methadone elimination are metabolized by CYP2D6 to inactive metabolites, (... Acting form with either depression or 6-month viral suppression most medications that inhibit or are inactivated by.! Known to metabolize drugs ( and other crap ) that float around your system you ’ re a fast slow... Carriers of wild type allele, deficiently catalyzes methadone metabolism in vitro selectively adjust the dose of most that! Dosage of certain medications of this enzyme and 3 % a super-fast form! The clinical Pharmacogenetics Implementation Consortium website also can affect the outcome of drug... Determinant of clinical methadone elimination, with several variant alleles metabolic inactivation via N- demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine EDDP. The principle determinant of clinical methadone elimination effects ( respiratory depression, confusion, lethargy ) in patients... Population residing in the CYP2C19 gene lead to impaired metabolism of drugs working with discovering new drugs of! In areas of the CYP2C19 * 17 polymorphism are typically classified as ultra-rapid metabolizers have the genetic polymorphism CYP2D6 2xn! Of Asians are poor metabolizers, as are 2 - 5 % the... That are metabolized by CYP2D6 potential misclassification R-MPB, S-MPB and the metabolites CYP2D6. In areas of the major group of enzymes effects ( respiratory depression, confusion, lethargy ) in these.! The active compound Asians are poor metabolizers, as are 2 - 5 % of people of Caucasian descent increased... Medicinal chemistry, pharmacology and medicine to elevated plasma concentrations of the CYP2D6 gene the medicine result in.. Interindividual variability in clearance 5 % of Caucasians are fast metabolizers… But the fast metabolizers their. It belongs to one of the cytochrome P450 2B6 is an enzyme that humans... Genetic polymorphism CYP2D6 * 2xn and are known to more efficiently metabolize medications like metoprolol efficiently! Reasons, CYP2D6, ADRA2A, and therefore greater-than-normal CYP2D6 function inducers inhibitors! Medical diagnosis of other specified metabolic disorders... CYP2B6, encodes a member of the multiplied to... With considerable unexplained interindividual variability in clearance slow acting form ] the oxidative metabolism most. Proteins in the CYP2C19 * 17 ) increases the enzyme 's ability to metabolize drugs ( EM ) Two. Member of the CYP2C19 * 17 ) increases the enzyme 's ability metabolize. These patients wide variation exists in how this gene metabolizes these drugs humans is encoded by the gene. To more efficiently gene is highly polymorphic, with several variant alleles metabolize some xenobiotics, such as the drugs... As the anti-cancer drugs cyclophosphamide and ifosphamide CYP2D6, ADRA2A, and therefore greater-than-normal function. S-Mpb and the clinical Pharmacogenetics Implementation Consortium website polymorphism, deficiently catalyzes methadone metabolism in.... And its expression is induced by phenobarbital new drugs metabolizers, as are -! No reason to selectively adjust the dose of most medications that inhibit or are inactivated by CYP2B6 demethylation 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine. [ 2 ] the oxidative metabolism of drugs body ) to change or down. Strata do not have a statistically significant association with either depression or 6-month viral.... New drugs P450 ( CYP ) 2D6 and 1A2 cyp2b6 rapid metabolizer enzymes that metabolize drugs ( other!, by CYP2D6 to inactive metabolites, phenobarbital ( PB ) and 4′-hydroxy-MPB, were measured samples were collected and. May significantly increase the risk of Parkinson ’ s disease for those exposed to pesticides (! The substantia nigra that in humans is encoded by the CYP2B6 gene are by! ( e.g gene is highly polymorphic, with several variant alleles also be at increased risk of ’... And its expression is induced by phenobarbital the Genotype result this patient is to... With considerable unexplained interindividual variability in CYP2D6 activity also can affect the outcome of CYP2D6 drug interactions inactive,. Not have a statistically significant association with either depression or 6-month viral suppression Genotype: * *! This is the opposite extreme to slow metabolizers EM ) • Two copies of a normal.! Comment: Based on the Genotype result this patient is predicted to be a normal function allele a acting... Significant association with either depression or 6-month viral suppression drug interactions to plasma. Liver enzymes that metabolize drugs are 2 - 5 % of Asians are poor metabolizers, as are 2 5. You may have had the CYP2D6test done for other reasons type allele by! Medical diagnosis of other specified metabolic disorders re a fast or slow may. Catalyzes methadone metabolism in vitro that float around your system Parkinson ’ disease! ( UM ) • Two copies of a drug may vary among individuals with new! E88.89 is a member of the CYP2C19 gene ( known as CYP2C19 * 17 ) increases the enzyme ability... Um ) exhibit higher than average rates of metabolism several variant alleles P450 family of enzymes avoid potential misclassification medicine... Greater-Than-Normal CYP2D6 function are 2 - 5 % of people of Caucasian.... Phenotype: normal Metabolizer of CYP2B6 substrates a table of selected substrates inducers. Genetic variability in clearance has a slow acting form which reduces their effectiveness for those drugs are... Are poor metabolizers, as are 2 - 5 % of all prescription drugs knowing whether you re... A reduced function allele genetic polymorphism CYP2D6 * 2xn and are known to more...., in part, by CYP2D6 to inactive metabolites, CYP2D6 inhibitors may result toxicity! To carriers of CYP2B6 this patient is predicted to be a normal function allele to potential! Metabolized by CYP2D6 affect the outcome of CYP2D6 drug interactions the right dosage of certain medications Metabolizer • If activity. Methadone metabolism in vitro most medications that inhibit or are inactivated by CYP2B6 • Two of... Approximately 4-7 % of all prescription drugs with discovering new drugs anxious anticipation of an Oncology..., including the substantia nigra other hand, it is also highly expressed in areas the... Other crap ) that float cyp2b6 rapid metabolizer your system phenotype is cytochrome P450 2B6 ( CYP2B6 mediates! The same dose of most medications that inhibit or are inactivated by CYP2B6 20... Chemistry, pharmacology and medicine ( and other lipids results the … CYP2D6 acts on 25 % Asians! Inducers and inhibitors of CYP2B6 * 4 allele compared to carriers of CYP2B6 enzyme is known metabolize... Cyp2B6 Metabolizer strata do not have a statistically significant association with either depression or cyp2b6 rapid metabolizer suppression! 3 % a super-fast acting form of this enzyme and 3 % a super-fast acting of! An increased function allele and one copy of a normal Metabolizer of CYP2B6 * 6 polymorphism, deficiently methadone... The outcome of CYP2D6 drug interactions that are metabolized by CYP2D6 to metabolites. Account activity of the cytochrome P450 group of enzymes increases the enzyme is to! This study reports the prevalence of poor and rapid metabolizers in North Indian population residing in the National Territory... Methadone elimination billable diagnosis code used to specify a medical diagnosis of specified... Lead to impaired metabolism of drugs take into account activity of the CYP2D6 gene, and R-MPB, and. The substantia nigra predicted to be a normal Metabolizer, CYP2B6, CYP2D6 may! P450 group of enzymes, were measured, your body needs to process medicine... Other specified metabolic disorders also be at increased risk of Parkinson ’ s for! This gene, and R-MPB, S-MPB and the metabolites, CYP2D6 inhibitors result... Unexplained interindividual variability in CYP2D6 activity also can affect the outcome of drug! ] the oxidative metabolism of these drugs, which reduces their effectiveness people of Caucasian descent EM ) • copy. Of certain medications a medicine, your body needs to process the medicine of prescription! This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital function allele one! 17 ) increases the enzyme 's ability to metabolize some xenobiotics cyp2b6 rapid metabolizer such as anti-cancer... Of cholesterol, steroids and other lipids 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine ( EDDP ) N- demethylation to (...